Comprehensive Textbook of Medical Physiology, 5th Edition, by G K Pal with co-authors Pravati Pal and Nivedita Nanda, is a two-volume Physiology textbook fully revised and aligned with the latest CBME guidelines prescribed by the National Medical Commission (NMC), 2024. Presented with a Clinically Integrated Approach, this edition maps core physiological concepts to their clinical relevance for the Revised Competency-based Medical Education Curriculum. Each chapter organizes Learning Objectives into "Must Know" and "Desirable to Know" categories for focused, exam-oriented study, and closes with a Chapter Summary for quick end-of-topic revision. Dedicated Application Boxes, Clinical Boxes, and "Scientist Contributed" boxes connect physiological mechanisms to bedside relevance, while Important Notes highlight key facts for easy retention. The two volumes are further supported by print-plus-digital ConceptRx access, adding exam-focused revision tools such as chapter summaries, notes, mind maps, and PYQs alongside the printed text.