This book is strictly written according to the new curriculum proposed by Medical Council of India (MCI). Each practical/chapter has been aligned with the competency and the specific learning objectives are framed accordingly. It comprehensively covers the self-directed learning modules, clinical case scenarios for early clinical exposure. The section on calculations emphasizes on the measurement and calculation of various physiological parameters like cardiac output, glomerular filtration rate (GFR), etc. This workbook is divided into six sections: Hematology, Experimental Physiology, Human and Clinical Physiology including Human Experiments and Demonstrations, Self-directed Learning (SDL) & Early Clinical Exposure (ECE), Calculations, and Spots. In each chapter equal importance has been given to three segments, namely-Theory, Observation and Questions. As spotting is an important part of examination, spots segment has been included which comprehensively reviews important spots.