The practical handbook of pharmaceutics practical - I has been written for students of master of pharmacy first-year students keeping in mind specific requirements of the Pharmacy Council of India (PCI), Education Regulation - 2020.This practical book is covering the entire practical syllabus of pharmaceutics I Semester as per new PCI norms recognized as MPH105P. This practical handbook containing twenty experiments. This book mainly guides students to get knowledge about the various approaches for development of novel drug delivery systems, practical skills of the instruments and preformulation studies. Students will find it a clear and concise overview of pharmaceutics laboratory work. Most of the informations in this book has represented in a very simple manner. The aim of this book is to make the subject easy and understandable to the students. It aims at giving a good exposure of various aspects including the role of pharmaceutics in Pharmacy. These practical handbooks mainly aim in guiding the post graduate students and overcoming the obstacles faced by them in practical aspects of pharmaceutics. This practical handbook tries to cover the syllabus of pharmaceutics practical I from most of the university from India. The Practical handbook will certainly contribute to the enhancement of the skills and competency with the professional services at the level of national health.I would also like to acknowledge my colleagues and students for their willingness to serve.