Practical Manual of Pharmacology for Medical Students has been developed in alignment with the updated pharmacology competencies as per CBME 2024 curriculum, incorporating contemporary approaches to teaching?learning and assessment. The manual comprehensively addresses newly introduced curricular elements scenario-based exercises that promote experiential learning. All certifiable competencies are systematically included along with structured formats for documentation and completion. Students can directly use it as manual and add their observations and inferences at end of chapters in the workbook exercises pages. The Emphasis has been placed on psychomotor competencies, supplemented with relevant cognitive, attitudinal, and communication domains essential for holistic skill development. The manual also features a wide range of application-oriented exercises to strengthen understanding of clinical pharmacology in real-world contexts. Updated chapters cover key areas such as communication, technical and procedural skills, simulation, pharmacoeconomics, rational prescribing, emerging teaching methodologies, and modern assessment strategies. In addition, the content integrates the latest national standard treatment guidelines, recent advances in drug formulations, updated regulations concerning drugs and clinical trials, and ethical considerations. Designed to meet the needs of undergraduate medical students, the manual is equally valuable for dental students and postgraduate learners in pharmacology. It serves as a versatile resource?functioning as a practical manual, a teaching aid, a reference text, and a useful guide for assessment stations.