Critical care medicine is a relatively new but pivotal medical specialty, which has seen drastic growth in the current decade. The ICU Manual (2nd edition) focuses on the basic as well as core principles of intensive care which would be of great benefit to every practicing intensivist and postgraduate in anesthesiology, internal medicine, and invariably every medical and surgical specialty. Stream-lined scientific content with clear concepts and ready reckoners will equip the reader for confident critical care practice. Expert contributions from various specialties have made the manual comprehensive and more authentic. Current guidelines on sepsis, deep vein thrombosis (DVT), and cardiopulmonary resuscitation (CPR) and chapters on COVID-19, oncological emergencies, and echocardiogram in ICU are the new additions. POCUS in Critical Care with supporting images and videos is the outstanding feature of this manual. The evidence of POCUS in critical care has tremendously increased in the recent past, which has significantly changed the practice of intensive care in certain areas.